The Epigenetics Center of the Institute for Basic Biomedical Sciences is bringing together an outstanding team of multidisciplinary investigators to explore the epigenetic basis of normal development and disease. One of the Center’s major goals is to develop novel technology that will provide cutting edge tools to the Hopkins community allowing our scientists to make the first discoveries in this exciting frontier.

The Center of Excellence in Genomic Science (CEGS) at Johns Hopkins is a multi-investigator, interdisciplinary research effort focused on understanding the epigenetic basis of common human diseases, including age-related illnesses, neuropsychiatric disease, and cancer. CEGS has developed new genome-scale tools to explore the idea epigenetic variation may be at least as great between individuals as variations in the DNA sequences themselves. Understanding the epigenome may help explain how errors occur in normal development and how environmental factors lead to cancer, autism and other disorders.

Understanding how the information in the human genome is utilized is one of the central questions in modern biology. It has become clear that a critical level of gene regulation occurs through the chemical modification of both the DNA itself and the proteins that organize eukaryotic DNA into chromatin. This form of gene regulation, termed epigenetics, refers to cellular “memory” other than the DNA sequence alone, and occurs through mechanisms involving chromatin modification and remodeling.

Center for Epigenetics Lab Sites

About the JHU Center for Epigenetics

Find out more about our mission and research goals at the Center for Epigenetics.

Koldobskiy Lab

Michael Koldobskiy, M.D., M.S., Ph.D.
Instructor of Oncology

Feinberg Lab

Andrew Feinberg, MD, MPH
Director, Center for Epigenetics

Reddy Lab

Karen L. Reddy, Ph.D.
Assistant Professor of Biological Chemistry

Kalhor Lab

Reza Kalhor, Ph.D.
Assistant Professor

Taverna Lab

Sean Taverna, Ph.D.
Associate Professor, Pharmacology and Molecular Sciences